Although the set of bacteria in healthy and sick people is the same, microbes act differently.
Researchers from the Center for Biomedical Systems of Luxembourg (LCSB) conducted a genetic analysis of DNA and RNA of bacteria in the intestinal ecosystem of healthy people and patients with type I diabetes. As a result, the possibility and mechanism of the influence of intestinal microflora on the course of the disease were revealed: journal Nature Microbiology.
In their composition, the bacteria inhabiting the feces of healthy and diabetic people almost do not differ, however, serious differences have been found in the vital activity of microorganisms.
In type I diabetes, insulin-producing cells are attacked by the body’s own immune system, which affects the pancreas. Intestinal bacteria tend to adapt to these changes in the host body and produce vitamins in other quantities, in particular, thiamine. Altered thiamine levels may worsen the course of the disease. Thus, the normal microflora becomes an additional risk factor.