Blood diseases constitute a numerous and heterogeneous group of syndromes that develop with violations of the qualitative and quantitative composition of blood. The practical direction developing the principles of diagnosis and treatment of blood diseases is hematology and its separate branch – oncohematology. Specialists who carry out correction of the state of blood and hematopoietic organs are called hematologists. Hematology has the closest interdisciplinary connections with internal diseases, immunology, oncology, and transfusiology.

Since ancient times, in many cultures, human blood was endowed with mystical properties, symbolized the divine source and flow of life. “Precious”, “hot”, “innocent”, “young”, “royal” – whatever properties people gave blood, and the epithet “blood” always meant the highest degree of certain manifestations – blood kinship, blood enemy, blood grudge, blood revenge.

what is hiv (what is AIDS)
what is hiv (what is AIDS)

Meanwhile, from the point of view of physiology, blood is a liquid medium of the body that continuously circulates through the vascular system and performs a number of important functions – respiratory, transport, regulatory, protective, etc. Blood consists of a liquid fraction – plasma and shaped elements suspended in it – blood cells (erythrocytes, platelets and leukocytes). The main organs of hematopoiesis (hemocytopoiesis), which are a kind of “factory” for the production of blood cells, include the red bone marrow, thymus, lymphoid tissue and spleen. Blood diseases are spoken of in the case of a violation of the morphology or the number of certain blood cells or changes in the properties of plasma.

All diseases of the blood and hematopoietic system are classified based on the defeat of one or another of its components. In hematology, blood diseases are usually divided into three large groups: anemia, hemoblastosis and hemostasiopathy. So, frequent anomalies and lesions of erythrocytes include deficient, hemolytic, hypo– and aplastic anemia. The structure of hemoblastoses includes leukemias and hematosarcomas.

Blood diseases associated with damage to the hemostatic system (hemostasiopathy) include hemophilia, Willebrand’s disease, thrombocytopathies, thrombocytopenia, DIC syndrome, etc.

Blood diseases can be congenital and acquired in nature. Congenital diseases (sickle cell anemia, thalassemia, hemophilia, etc.) are associated with gene mutations or chromosomal abnormalities. The development of acquired blood diseases can be triggered by numerous environmental factors: acute and chronic blood loss, exposure to ionizing radiation or chemical agents, viral infections (rubella, measles, mumps, influenza, infectious mononucleosis, typhoid fever, viral hepatitis), nutritional deficiency, impaired absorption of nutrients and vitamins in the intestine, etc. When bacterial or fungal agents enter the bloodstream, a serious blood disease of infectious genesis occurs – sepsis. Many blood diseases go hand in hand with collagenoses.

The manifestations of blood diseases are many-sided and not always specific. Characteristic signs of anemia are causeless fatigue and weakness, dizziness up to fainting, shortness of breath during physical exertion, pallor of the skin. Disorders of the blood coagulation link are characterized by petechial hemorrhages and ecchymoses, various kinds of bleeding (gingival, nasal, uterine, gastrointestinal, pulmonary, etc.). In the leukemia clinic, intoxication or hemorrhagic syndromes come to the fore.

The very first method with which the diagnosis of blood diseases begins is the study of a hemogram (clinical analysis) with the determination of the quantitative composition of blood and the morphology of the shaped elements. In blood diseases occurring with hemostasis disorders, the number of platelets, blood clotting and bleeding time, prothrombin index, coagulogram are examined; various kinds of tests are carried out – a tourniquet test, a pinch, a cupping test, etc.

To assess the changes occurring in the hematopoietic organs, bone marrow puncture (sternal puncture, iliac puncture, trepanobiopsy) is used with the study of its cellular composition. In connection with blood diseases, other invasive diagnostic interventions may be performed: biopsies of the lymph nodes and spleen to clarify the relationship between the central and peripheral hematopoietic organs.

Radiation research methods (chest X-ray and CT, radiography of tubular bones) are used to detect enlarged mediastinal lymph nodes in lymphogranulomatosis, lymphosarcoma, lymphocytic leukemia; bone lesions in lymphomas, myeloma, etc. To assess the size, function of the spleen and identify its focal lesions, scintigraphy is performed. As part of the investigation of the causes of the anemia syndrome, patients may need to consult a gastroenterologist and gynecologist; FGDS, colonoscopy, liver ultrasound.

Any changes in the hemogram or myelogram, as well as symptoms indicating the likelihood of developing blood diseases, require a competent assessment by a hematologist, dynamic observation or specialized treatment under his supervision. Modern hematology has developed the fundamental principles of therapy for various blood diseases and has accumulated vast experience in their cure. If possible, the treatment of blood diseases begins with the elimination of causes and risk factors, correction of internal organs, replenishment of missing substances and trace elements (iron – with iron deficiency anemia, vitamin B12 – with B12 deficiency anemia, folic acid – with folic deficiency anemia, etc.).

In some cases, corticosteroids, hemostatic drugs, extracorporeal hemocorrection (plasmapheresis, erythrocytapheresis) may be indicated. Often, hematological patients need blood transfusion and its components.

Cytostatic therapy, radiotherapy, allogeneic and autologous bone marrow transplantation, and the introduction of stem cells are the most relevant and effective methods of treating hematoblastosis worldwide. A number of blood diseases (thrombocytopenic purpura, autoimmune anemia, myeloid leukemia, etc.) are indications for spleen removal – splenectomy.

With the current level of development of medical science, most blood diseases can be cured and prevented. To do this, it is necessary to take a general blood test every year, immediately consult a doctor when the first alarming symptoms appear, do not start the course of chronic diseases (erosive gastritis, gastric ulcer, enteritis, NYAK, hemorrhoids, uterine fibroids, etc.). It is necessary to avoid exposure to adverse environmental factors on the body. To exclude the birth of offspring with congenital blood diseases, medical and genetic consultations are conducted.
In this section of the medical reference book “Medic Journal” you will be able to find answers to the main questions concerning blood diseases, get acquainted with the main nosological forms, symptoms, principles of diagnosis and treatment.

hemoblastosis

Hemoblastosis

Hemoblastosis are bone marrow and extra-bone marrow neoplastic processes represented by two groups of diseases – myeloproliferative (leukemia) and lymphoproliferative (hematosarcoma). Hyperplastic, intoxication, hemorrhagic, anemic, immunodeficiency syndromes are common for all forms. Diagnosis includes a general blood test; sternal puncture, trepanobiopsy, lymph node biopsy with examination of the material; instrumental studies (ultrasound, radiography). Treatment of…

hairy cell leukemia

Hairy Cell Leukemia

Hairy cell leukemia is a chronic B-cell lymphoproliferative process that occurs with a predominant lesion of the bone marrow and spleen. Clinically manifested by hepatosplenomegaly, lymphadenopathy, lymphocytosis with “hairy” lymphocytes, pancytopenia. The diagnosis is established taking into account the data of the blood picture, immunophenotyping of lymphocytes, ultrasound / CT of abdominal organs, bone marrow…

thrombotic microangiopathy

Thrombotic Microangiopathy

Thrombotic microangiopathy is a polysyndromic pathology that combines thrombocytopenia, hemolytic anemia, arteriole occlusion with the development of ischemic organ lesions. Clinically, it proceeds with fever, bleeding, neurological disorders, abdominal syndrome. Possible development of TIA, myocardial and kidney infarction, hepatitis, mesenteric ischemia. Diagnosis is based on the study of blood (UAC, platelets, LDH, metalloproteinase activity), kidney…

willebrand disease

Willebrand Disease

Willebrand disease is a congenital pathology of hemostasis, manifested by quantitative and qualitative deficiency of Willebrand plasma factor and increased bleeding. Willebrand disease is characterized by spontaneous formation of subcutaneous petechiae, ecchymoses; recurrent bleeding from the nose, gastrointestinal tract, uterine cavity; excessive blood loss after injuries and operations, hemarthrosis. The diagnosis is established according to…

aplastic anemia

Aplastic Anemia

Aplastic anemia is an inhibition of the hematopoiesis function of the red bone marrow (erythrocytopoiesis, leukopoiesis and thrombocytopoiesis), leading to pangemocytopenia. The main clinical manifestations of the hematological syndrome include dizziness, weakness, fainting, shortness of breath, tingling in the chest, skin hemorrhages, bleeding, a tendency to develop infectious-inflammatory and purulent processes. The disease is diagnosed…

diamond-blackfan anemia

Diamond-Blackfan Anemia

Diamond-Blackfan anemia is a hereditary form of red cell aplasia with a reliably unexplored type of inheritance (an autosomal dominant type of inheritance is assumed to occur in a quarter of patients). The symptoms of the disease are anemic manifestations that occur, as a rule, during the first year of life – pallor, weakness, increased…

agranulocytosis

Agranulocytosis

Agranulocytosis is a clinical and hematological syndrome, which is based on a sharp decrease or absence of neutrophil granulocytes among the cellular elements of peripheral blood. The disease is accompanied by the development of infectious processes, sore throat, ulcerative stomatitis, pneumonia, hemorrhagic manifestations. Of the complications, sepsis, hepatitis, mediastinitis, peritonitis are frequent. Of paramount importance…