The specific flexibility of brain enzymes can be used in the treatment of diabetes. This conclusion was reached by scientists from the University of Wisconsin Madison in the USA.
Enzymes could become more effective in the treatment of diabetes, having specific flexibility and the ability to move between different forms. This study may improve the process of drug development for diabetic patients, as well as other promising enzymes for therapeutic purposes. In addition, this discovery refuted the widespread opinion that the molecular signaling mechanism in the body is based on the presence of one ideal and static partner for the activation of cellular receptors.
Now it has been proved that the mechanisms of vital activity can be more dynamic than previously thought. It was previously known that an enzyme called GLP-1 takes a rigidly spiral corkscrew shape. And compared to the enzyme enclosed in this form, another enzyme designed to form a bend near its end activated the cellular target better. And this contributed to the release of insulin from the pancreas.
It cannot be excluded that in the human body GLP-1 will be able to switch between these two forms, which will make it the most effective treatment for diabetes. Many hormones are enzymes, including insulin and GLP-1. They provide key information to cells that affect metabolism. For example, by controlling blood sugar levels.